Welcome, Barb.
Given the opportunity to design in advance I'd always plan for a mud bed in the tile areas. That would involve dropping those areas below the adjacent subflooring, then mudding them back up to exactly the desired height come time for tile. Dropping the tile areas 1 1/2" below the adjacent subflooring gives you plenty room for more than the minimum requirement of 1 1/4" of reinforced deck mud.
There are many manufacturer's of tiling substrates who will accept nothing more than a 5/8" layer of plywood over 16"oc joist spacing. I don't like minimum requirements, much, and I like that minimum even less. Not sure why you are planning for 12"oc joist spacing, but that does help in the subflooring arena.
If I elected to have only subflooring and a more contemporary tiling substrate I would plan for a 3/4" subfloor topped by another layer of 1/2" subflooring. Then my CBU or membrane of choice.
My opinion; worth price charged.