Hi, how about a name?
A curb built like your old one is pretty standard. I suppose you could go a bit smaller in both dimensions but I wouldn't be comfortable at all with 2x2 (which you probably mean built from 1.5" x 1.5" lumber.) For strength considerations I would reduce the height before I would reduce the width, which is probably "the lady's" main concern.
Regarding your drain, pictures would be most helpful. Your drain can probably be lowered, you will probably have to remove some concrete around the drain any event to adapt to the Kerdi system.
Finally, most sliding shower doors are pretty thin (2" or so) so they would work on a thinner curb, but again I wouldn't reduce the curb width much.
Good luck!