I think that I'd treat the towel bar ends as if they were a tile. The overlay on the toilet paper holder isn't very large, and I think that I'd use some color matched or clear silicone caulk/sealant to hold it into the hole.
Given their shape, especially the towel bar ends, you may want to use some tape to hold them in place while the mortar cures. I'm guessing that you'll need to install the towel bar as you're mounting them, and that will add some extra weight that could make the ends come out or tip some.
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Jim DeBruycker
Not a pro, multiple Schluter Workshops (Schluterville and 2013 and 2014 at Schluter Headquarters), Mapei Training 2014, Laticrete Workshop 2014, Custom Building Products Workshop 2015, and Longtime Forum Participant.
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