Welcome, Ripp.

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Originally Posted by Ripp
Is plywood alone an acceptable substrate to thinset stone over?
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The requirements for setting even ceramic tile directly to plywood are very strict and usually not readily achievable in a remodel situation. In any case, we generally recommend pretty strongly against it. I'd not recommend it at all for natural stone.
Quote:
Originally Posted by Ripp
How should I over come any problems with level in terms of the elevation change from wood to slab?
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I trust we're talking about flat, rather than level. You will need to honor that joint between the two subfloors all the way up through your tile surface in any case. Dealing with a change in elevation there will depend upon how much change, where it falls in your design, etc. But it'll be a consideration, for sure.
Quote:
Originally Posted by Ripp
Should I have a moisture barrier over the slab like Redguard or something? Never had any problems with moisture before.
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Only if you have a problem. But you may want to use an uncoupling membrane over the slab anyway, and that may well serve as a moisture barrier, too.
Tape a couple squares of clear polyethylene sheeting, about two by two feet in size, to the slab for a couple days and see if you observe any visible moisture. If you do, you'll wanna do a more serious test before you proceed. If not, I wouldn't worry about it.
You also need to evaluate the joist structure under the framed portion of the floor. You can enter the necessary information into our (Deflecto) above and get a good initial indication. You must also have two layers of plywood or OSB subflooring, properly installed, for any natural stone installation.
Still a bit of research needed on your part to sort it all out.
My opinion; worth price charged.