I have another way of looking at this having dealt with it twice now on showers I was kerdi'n ( the drywall guys mudded and painted the enclosure)
It seems to me the paint in most cases helps the thinset bond..especially latex. If you rough it up you get into a bunch of exposed gypsum mud and thinset and gypsum tend not to work as well together. I think I would key thinset into the painted texture with the flat side of the trowel...let it cure as a bondcoat if possible, (that will help take some of the variation out if it's a bit too textured) and then tile. I've done this with kerdi and tested spots on the wall. I know your bond is only as good as the paint, but in my case it bonded very well.
Just a thought.